Isoform-specific functions in pancreatic adenocarcinoma

Exocrine pancreatic adenocarcinoma in a toy breed dog

A 4-year-old female miniature pincher with a 40-day history of weight loss, lethargy and vomiting was referred to Small Animal Hospital, Faculty of Veterinary Medicine, University of Tehran. The case also had severe jaundice, chronic diarrhoea and steatorrhoea. The efforts for saving the life of the case were not successful and finally the animal died of hypovolaemic shock and electrolyte imbal...

Pancreatic adenocarcinoma in a patient with relapsed Hodgkin’s lymphoma

After curative treatment of Hodgkin’s lymphoma, increased risk of certain solid tumors has been reported. To best of our knowledge this is the first report of metachronous pancreatic adenocarcinoma which developed outside the previous radiation field in a patient with relapse Hodgkin’s lymphoma. Herein we present an 81-year-old female who developed pancreatic adenocarcinoma four yea...

Pancreatic Adenocarcinoma NCCN Pancreatic Adenocarcinoma Panel Members

Chemotherapy in pancreatic adenocarcinoma.

Pancreatic cancer is a malignancy with a very poor prognosis, even when radically resected. In advanced disease chemotherapy has a role in terms of clinical benefit and symptoms palliation, more than survival advantage. Gemcitabine as a single agent is the first-line standard treatment since 1997. Several trials failed to demonstrate a survival advantage of chemotherapy doublets or gemcitabine ...

Isoform-specific functions of protein kinase C: the platelet paradigm.

Platelets are central to haemostasis and thrombosis. Many key steps in platelet activation and aggregation are regulated by members of the PKC (protein kinase C) family. Multiple isoforms of PKC are expressed in platelets, and evidence is emerging that different isoforms play distinct roles in the platelet activation process. This may, in part, be regulated by isoform-specific interactions betw...